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Selective requirement for Mediator MED23 in Ras-active lung cancer
K-RAS–activating mutations occur frequently in non-small cell lung cancer, leading to aberrant activation of the Ras–MAPK signaling pathway that contributes to the malignant phenotype. However, the development of Ras-targeted therapeutics remains challenging. Here, we show that MED23, a component of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478617/ https://ncbi.nlm.nih.gov/pubmed/22988093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204311109 |
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