Dicyanovinylnaphthalenes for neuroimaging of amyloids and relationships of electronic structures and geometries to binding affinities

The positron-emission tomography (PET) probe 2-(1-[6-[(2-fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene) (FDDNP) is used for the noninvasive brain imaging of amyloid-β (Aβ) and other amyloid aggregates present in Alzheimer’s disease and other neurodegenerative diseases. A series of FDDNP analogs h...

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Detalhes bibliográficos
Main Authors: Petrič, Andrej, Johnson, Scott A., Pham, Hung V., Li, Ying, Čeh, Simon, Golobič, Amalija, Agdeppa, Eric D., Timbol, Gerald, Liu, Jie, Keum, Gyochang, Satyamurthy, Nagichettiar, Kepe, Vladimir, Houk, Kendall N., Barrio, Jorge R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478600/
https://ncbi.nlm.nih.gov/pubmed/23012452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214134109
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