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Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly

Aging is closely associated with muscle insulin resistance, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. We examined the hypothesis that muscle insulin resistance in healthy aging promotes increased hepatic de novo lipogenesis (DNL) and hyperlipidemia by altering th...

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Detalhes bibliográficos
Main Authors: Flannery, Clare, Dufour, Sylvie, Rabøl, Rasmus, Shulman, Gerald I., Petersen, Kitt Falk
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478531/
https://ncbi.nlm.nih.gov/pubmed/22829450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0206
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