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Zeptomole detection of DNA nanoparticles by single-molecule fluorescence with magnetic field-directed localization
Single-molecule fluorescence methods offer the promise of ultrasensitive detection of biomolecules, but the passive immobilization methods commonly employed require analyte concentrations in the picomolar range. Here, we demonstrate that superparamagnetic Fe(3)O(4) nanoparticles (NPs) can be used wi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478425/ https://ncbi.nlm.nih.gov/pubmed/22929698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2012.08.017 |
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