Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism

N-acetylglucosamine (GlcNAc), the monomer of chitin and constituent of bacterial peptidoglycan, is a preferred carbon and nitrogen source for streptomycetes. Recent studies have revealed new functions of GlcNAc in nutrient signaling of bacteria. Exposure to GlcNAc activates development and antibioti...

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Bibliografske podrobnosti
Main Authors: Świątek, Magdalena A., Urem, Mia, Tenconi, Elodie, Rigali, Sebastien, van Wezel, Gilles P.
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Research Note
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477696/
https://ncbi.nlm.nih.gov/pubmed/22892576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bioe.21371
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