The pharmacokinetics of oxypurinol in people with gout

AIMS: Our aim was to identify and quantify the sources of variability in oxypurinol pharmacokinetics and explore relationships with plasma urate concentrations. METHODS: Non-linear mixed effects modelling was applied to concentration–time data from 155 gouty patients with demographic, medical histor...

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Detalhes bibliográficos
Main Authors: Stocker, Sophie L, McLachlan, Andrew J, Savic, Radojka M, Kirkpatrick, Carl M, Graham, Garry G, Williams, Kenneth M, Day, Richard O
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477349/
https://ncbi.nlm.nih.gov/pubmed/22300439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04207.x
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