Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis

AIMS: Cyclophosphamide, the precursor to the active 4-hydroxycyclophosphamide, is used in active glomerulonephritis despite limited pharmacokinetics data. The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide were evaluated. The influence of laboratory and pharmacogenomic covariates...

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Detalhes bibliográficos
Main Authors: Joy, Melanie S, La, Mary, Wang, Jinzhao, Bridges, Arlene S, Hu, Yichun, Hogan, Susan L, Frye, Reginald F, Blaisdell, Joyce, Goldstein, Joyce A, Dooley, Mary Anne, Brouwer, Kim L R, Falk, Ronald J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477346/
https://ncbi.nlm.nih.gov/pubmed/22380717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04223.x
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