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Extension of the CHARMM General Force Field to Sulfonyl-Containing Compounds and Its Utility in Biomolecular Simulations

Presented is an extension of the CHARMM General force field (CGenFF) to enable the modeling of sulfonyl-containing compounds. Model compounds containing chemical moieties such as sulfone, sulfonamide, sulfonate and sulfamate were used as the basis for the parameter optimization. Targeting high-level...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yu, Wenbo, He, Xibing, Vanommeslaeghe, Kenno, MacKerell, Alexander D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477297/
https://ncbi.nlm.nih.gov/pubmed/22821581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.23067
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