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Rationalization of paclitaxel insensitivity of yeast β-tubulin and human βIII-tubulin isotype using principal component analysis

BACKGROUND: The chemotherapeutic agent paclitaxel arrests cell division by binding to the hetero-dimeric protein tubulin. Subtle differences in tubulin sequences, across eukaryotes and among β-tubulin isotypes, can have profound impact on paclitaxel-tubulin binding. To capture the experimentally obs...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Das, Lalita, Bhattacharya, Bhabatarak, Basu, Gautam
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477043/
https://ncbi.nlm.nih.gov/pubmed/22849332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-5-395
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