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Thyroid Hormone Receptor Isoform-specific Modification by Small Ubiquitin-like Modifier (SUMO) Modulates Thyroid Hormone-dependent Gene Regulation

Thyroid hormone receptor (TR) α and β mediate thyroid hormone action at target tissues. TR isoforms have specific roles in development and in adult tissues. The mechanisms underlying TR isoform-specific action, however, are not well understood. We demonstrate that posttranslational modification of T...

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Detalhes bibliográficos
Main Authors: Liu, Yan-Yun, Kogai, Takahiko, Schultz, James J., Mody, Kaizeen, Brent, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476315/
https://ncbi.nlm.nih.gov/pubmed/22930759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344317
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