A Phytoestrogen Diarylheptanoid Mediates Estrogen Receptor/Akt/Glycogen Synthase Kinase 3β Protein-dependent Activation of the Wnt/β-Catenin Signaling Pathway

Estrogen promotes growth in many tissues by activating Wnt/β-catenin signaling. Recently, ASPP 049, a diarylheptanoid isolated from Curcuma comosa Roxb., has been identified as a phytoestrogen. This investigation determined the involvement of Wnt/β-catenin signaling in the estrogenic activity of thi...

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Detalhes bibliográficos
Main Authors: Bhukhai, Kanit, Suksen, Kanoknetr, Bhummaphan, Narumol, Janjorn, Keatdamrong, Thongon, Natthakan, Tantikanlayaporn, Duangrat, Piyachaturawat, Pawinee, Suksamrarn, Apichart, Chairoungdua, Arthit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476284/
https://ncbi.nlm.nih.gov/pubmed/22936801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344747
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