Cryptococcus neoformans Activates RhoGTPase Proteins Followed by Protein Kinase C, Focal Adhesion Kinase, and Ezrin to Promote Traversal across the Blood-Brain Barrier

Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Previous studies have demonstrated that Cryptococcus binding and invasion of human brain microvascular endothelial cells (HBMEC) is a prerequisite for transmigration across the blood-brain barrier. However,...

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Autores principales: Kim, Jong-Chul, Crary, Benjamin, Chang, Yun C., Kwon-Chung, Kyung J., Kim, Kee J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476282/
https://ncbi.nlm.nih.gov/pubmed/22898813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389676
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