The Structural Basis for a Coordinated Reaction Catalyzed by a Bifunctional Glycosyltransferase in Chondroitin Biosynthesis

Bifunctional chondroitin synthase K4CP catalyzes glucuronic acid and N-acetylgalactosamine transfer activities and polymerizes a chondroitin chain. Here we have determined that an N-terminal region (residues 58–134) coordinates two transfer reactions and enables K4CP to catalyze polymerization. When...

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Hlavní autoři: Sobhany, Mack, Kakuta, Yoshimitsu, Sugiura, Nobuo, Kimata, Koji, Negishi, Masahiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476270/
https://ncbi.nlm.nih.gov/pubmed/22936799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375873
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