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Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats

The model-based approach was undertaken to characterize the interaction between the peripheral and central antinociceptive effects exerted by lumiracoxib. The effects of intraplantar and intrathecal administrations and of fixed ratio combinations of lumiracoxib simultaneously administered by these t...

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Bibliografski detalji
Glavni autori: Vélez de Mendizábal, Nieves, Vásquez-Bahena, Dalia, Jiménez-Andrade, Juan M., Ortiz, Mario I., Castañeda-Hernández, Gilberto, Trocóniz, Iñaki F.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475850/
https://ncbi.nlm.nih.gov/pubmed/22968496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9405-y
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