Osteoprotegerin in Bone Metastases: Mathematical Solution to the Puzzle

Bone is a common site for cancer metastasis. To create space for their growth, cancer cells stimulate bone resorbing osteoclasts. Cytokine RANKL is a key osteoclast activator, while osteoprotegerin (OPG) is a RANKL decoy receptor and an inhibitor of osteoclastogenesis. Consistently, systemic applica...

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Bibliographic Details
Main Authors: Ryser, Marc D., Qu, Yiding, Komarova, Svetlana V.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475686/
https://ncbi.nlm.nih.gov/pubmed/23093918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002703
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