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An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in...

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Hlavní autoři: Thibodeaux, Gabrielle N., van der Donk, Wilfred A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475617/
https://ncbi.nlm.nih.gov/pubmed/23001385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc34138g
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