Structure-Activity Studies of RFamide-related Peptide-1 Identify a Functional Receptor Antagonist and Novel Cardiac Myocyte Signaling Pathway Involved in Contractile Performance

Human RFamide-related peptide-1 (hRFRP-1; MPHSFANLPLRF-NH(2)) binds to neuropeptide FF receptor 2 (NPFF(2)R) to dramatically diminish cardiovascular performance. hRFRP-1 and its signaling pathway may provide targets to address cardiac dysfunction. Here, structure-activity relationship, transcript, C...

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Detalhes bibliográficos
Main Authors: Nichols, Ruthann, Bass, Chloe, Demers, Leslie, Larsen, Brian, Li, Elton, Blewett, Nathan, Converso-Baran, Kimber, Russell, Mark W., Westfall, Margaret V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475511/
https://ncbi.nlm.nih.gov/pubmed/22909119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300760m
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