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Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle
Exercise-induced angiogenesis is a key determinant of skeletal muscle function. Here, we investigated whether the E3 ubiquitin ligase murine double minute-2 (Mdm2) exerts a proangiogenic function in exercised skeletal muscle. Mdm2 hypomorphic (Mdm2(Puro/Δ7-9)) mice have a 60% reduction in Mdm2 expre...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Federation of American Societies for Experimental Biology
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3475253/ https://ncbi.nlm.nih.gov/pubmed/22835827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-212720 |
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