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Oxydative stress alters nuclear shape through lamins dysregulation: A route to senescence
Progeroid phenotypes are mainly encountered in 2 types of syndromes: in laminopathies, which are characterized by nuclear shape abnormalities due to lamin A alteration, and in DNA damage response defect syndromes. Because lamin A dysregulation leads to DNA damages, it has been proposed that senescen...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3474660/ https://ncbi.nlm.nih.gov/pubmed/22895091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.21674 |
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