Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells

Estrogen and growth factors play a major role in uterine leiomyoma (UtLM) growth possibly through interactions of receptor tyrosine kinases (RTKs) and estrogen receptor-alpha (ERα) signaling. We determined the genomic and nongenomic effects of 17β-estradiol (E(2)) on IGF-IR/MAPKp44/42 signaling and...

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Main Authors: Yu, Linda, Moore, Alicia B., Castro, Lysandra, Gao, Xiaohua, Huynh, Hoang-Long C., Klippel, Michelle, Flagler, Norris D., Lu, Yi, Kissling, Grace E., Dixon, Darlene
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474284/
https://ncbi.nlm.nih.gov/pubmed/23094148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/204236
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