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Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin.

Opioid receptors on guinea pig brain membranes were alkylated by the naltrexone analogue beta-chlornaltrexamine. Binding of the prototypical mu and kappa ligands, [3H]dihydromorphine and [3H]ethylketocyclazocine, was more readily affected by the reagent than was binding of the delta ligand, 3H-label...

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Bibliografiska uppgifter
Huvudupphovsmän: James, I F, Chavkin, C, Goldstein, A
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1982
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC347382/
https://ncbi.nlm.nih.gov/pubmed/6130527
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