In depth comparison of an individual’s DNA and its lymphoblastoid cell line using whole genome sequencing

BACKGROUND: A detailed analysis of whole genomes can be now achieved with next generation sequencing. Epstein Barr Virus (EBV) transformation is a widely used strategy in clinical research to obtain an unlimited source of a subject’s DNA. Although the mechanism of transformation and immortalization...

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Bibliographic Details
Main Authors: Nickles, Dorothee, Madireddy, Lohith, Yang, Shan, Khankhanian, Pouya, Lincoln, Steve, Hauser, Stephen L, Oksenberg, Jorge R, Baranzini, Sergio E
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473256/
https://ncbi.nlm.nih.gov/pubmed/22974163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-477
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