NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression

Mutant KRAS in lung cancers induce molecular pathways that regulate cellular proliferation, survival and inflammation, which enhance tumorigenesis. Inducible nitric oxide synthese (NOS2) up-regulation and sustained nitric oxide (NO•) generation are induced during the inflammatory response and correl...

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Main Authors: Okayama, Hirokazu, Saito, Motonobu, Oue, Naohide, Weiss, Jonathan M., Stauffer, Jimmy, Takenoshita, Seiichi, Wiltrout, Robert H., Hussain, S. Perwez, Harris, Curtis C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473150/
https://ncbi.nlm.nih.gov/pubmed/22618808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27644
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