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Gene location and DNA density determine transcription factor distributions in Escherichia coli

The diffusion coefficient of the transcription factor LacI within living Escherichia coli has been measured directly by in vivo tracking to be D=0.4 μm(2)/s. At this rate, simple models of diffusion lead to the expectation that LacI and other proteins will rapidly homogenize throughout the cell. Her...

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Bibliografiske detaljer
Main Authors: Kuhlman, Thomas E, Cox, Edward C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472691/
https://ncbi.nlm.nih.gov/pubmed/22968444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2012.42
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