A theory of allelic and isotypic exclusion for immunoglobulin genes.
Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1982
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347257/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6817330/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.22.6976 |
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