Učitavanje...
Lys66 residue as a determinant of high mismatch extension and misinsertion rates of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT)
A major factor contributing to the high mutation rate of HIV-1 RT is its high propensity for misincorporation. Misincorporation requires both dNTP misinsertion and the subsequent extension of the mismatched terminus thus formed. We hypothesized that Lys66 is a determinant of mismatch extension based...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472125/ https://ncbi.nlm.nih.gov/pubmed/22925131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08807.x |
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