Thermal Unfolding Pathway of PHD2 Catalytic Domain in Three Different PHD2 Species: Computational Approaches

Prolyl hydroxylase domain 2 containing protein (PHD2) is a key protein in regulation of angiogenesis and metastasis. In normoxic condition, PHD2 triggers the degradation of hypoxia-inducible factor 1 (HIF-1α) that induces the expression of hypoxia response genes. Therefore the correct function of PH...

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Bibliografiske detaljer
Main Authors: Hadi-Alijanvand, Hamid, Proctor, Elizabeth A., Goliaei, Bahram, Dokholyan, Nikolay V., Moosavi-Movahedi, Ali A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471951/
https://ncbi.nlm.nih.gov/pubmed/23077544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047061
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