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Acyl-sulfamates Target the Essential Glycerol-Phosphate Acyltransferase (PlsY) in Gram-Positive Bacteria

PlsY is the essential first step in membrane phospholipid synthesis of Gram-positive pathogens. PlsY catalyzes the transfer of the fatty acid from acyl-phosphate to the 1-position of glycerol-3-phosphate to form the first intermediate in membrane biogenesis. A series of non-metabolizable, acyl-sulfa...

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Main Authors: Cherian, Philip, Yao, Jiangwei, Leonardi, Roberta, Maddox, Marcus M., Luna, Vicki A., Rock, Charles O., Lee, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471809/
https://ncbi.nlm.nih.gov/pubmed/22795901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.029
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