Regulation of Expression of Deoxyhypusine Hydroxylase (DOHH), the Enzyme That Catalyzes the Activation of eIF5A, by miR-331-3p and miR-642-5p in Prostate Cancer Cells

The enzyme deoxyhypusine hydroxylase (DOHH) catalyzes the activation of eukaryotic translation initiation factor (eIF5A), a protein essential for cell growth. Using bioinformatic predictions and reporter gene assays, we have identified a 182-nt element within the DOHH 3′-untranslated region (3′-UTR)...

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Detalhes bibliográficos
Main Authors: Epis, Michael R., Giles, Keith M., Kalinowski, Felicity C., Barker, Andrew, Cohen, Ronald J., Leedman, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471734/
https://ncbi.nlm.nih.gov/pubmed/22908221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374686
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