Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells

Corticotropin-releasing hormone (CRH) is secreted under stress and regulates the hypothalamic-pituitary-adrenal (HPA) axis. However, CRH is also secreted outside the brain where it exerts pro-inflammatory effects through activation of mast cells, which are increasingly implicated in immunity and inf...

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Autori principali: Asadi, Shahrzad, Alysandratos, Konstantinos-Dionysios, Angelidou, Asimenia, Miniati, Alexandra, Sismanopoulos, Nikolaos, Vasiadi, Magdalini, Zhang, Bodi, Kalogeromitros, Dimitrios, Theoharides, Theoharis C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471564/
https://ncbi.nlm.nih.gov/pubmed/22089831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2011.334
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