Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley rats

In this study we assessed the relative toxicity and potency of the chlorinated naphthalenes 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) and 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) relative to that of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Chemicals were administered in corn oil:acetone (99:1)...

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Detalhes bibliográficos
Main Authors: Hooth, Michelle J., Nyska, Abraham, Fomby, Laurene M., Vasconcelos, Daphne Y., Vallant, Molly, DeVito, Michael J., Walker, Nigel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471150/
https://ncbi.nlm.nih.gov/pubmed/22813907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2012.07.005
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