Generation of a Chinese Hamster Ovary Cell Line Producing Recombinant Human Glucocerebrosidase

Impaired activity of the lysosomal enzyme glucocerebrosidase (GCR) results in the inherited metabolic disorder known as Gaucher disease. Current treatment consists of enzyme replacement therapy by administration of exogenous GCR. Although effective, it is exceptionally expensive, and patients worldw...

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Autores principales: Novo, Juliana Branco, Morganti, Ligia, Moro, Ana Maria, Paes Leme, Adriana Franco, Serrano, Solange Maria de Toledo, Raw, Isaias, Ho, Paulo Lee
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471063/
https://ncbi.nlm.nih.gov/pubmed/23091360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/875383
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