Targeting the Oncogenic E3 Ligase Skp2 in Prostate and Breast Cancer Cells with a Novel Energy Restriction-Mimetic Agent

Substantial evidence supports the oncogenic role of the E3 ubiquitin ligase S-phase kinase-associated protein 2 (Skp2) in many types of cancers through its ability to target a broad range of signaling effectors for ubiquitination. Thus, this oncogenic E3 ligase represents an important target for can...

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Main Authors: Wei, Shuo, Chu, Po-Chen, Chuang, Hsiao-Ching, Hung, Wen-Chun, Kulp, Samuel K., Chen, Ching-Shih
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470570/
https://ncbi.nlm.nih.gov/pubmed/23071779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047298
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