PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion

Studies have shown that decreased mitochondrial content and function are associated with hepatic steatosis. We examined whether peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) overexpression and a subsequent increase in mitochondrial content and function in rat primary hepatocyt...

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Detalhes bibliográficos
Main Authors: Morris, E. Matthew, Meers, Grace M. E., Booth, Frank W., Fritsche, Kevin L., Hardin, Christopher D., Thyfault, John P., Ibdah, Jamal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469696/
https://ncbi.nlm.nih.gov/pubmed/22899824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00169.2012
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