Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

Although lipopolysaccharide (LPS) stimulation through the Toll-like receptor (TLR)-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature...

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Autors principals: Hajjar, Adeline M., Ernst, Robert K., Fortuno, Edgardo S., Brasfield, Alicia S., Yam, Cathy S., Newlon, Lindsay A., Kollmann, Tobias R., Miller, Samuel I., Wilson, Christopher B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469661/
https://ncbi.nlm.nih.gov/pubmed/23071439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002963
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