Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ(2)

We previously reported that acute inhibition of the RhoA/Rho kinase (ROCK) pathway normalized contractile function of diabetic rat hearts, but the underlying mechanism is unclear. Protein kinase C (PKC) β(2) has been proposed to play a major role in diabetic cardiomyopathy at least in part by increa...

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Detalhes bibliográficos
Main Authors: Soliman, Hesham, Gador, Anthony, Lu, Yi-Hsuan, Lin, Guorong, Bankar, Girish, MacLeod, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469644/
https://ncbi.nlm.nih.gov/pubmed/22865386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00416.2012
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