Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

NADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD(+)/NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the facilitation of NQO1 activity by feeding β-lapachone (βL), an exogenous NQO1 co-substrate, prevented...

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Detalhes bibliográficos
Main Authors: Lee, Jeong-sook, Park, Ah Hyung, Lee, Sang-Hee, Lee, Seoung-Hoon, Kim, Jin-Hwan, Yang, Suk-Jin, Yeom, Young Il, Kwak, Tae Hwan, Lee, Dongyeop, Lee, Seung-Jae, Lee, Chul-Ho, Kim, Jin Man, Kim, Daesoo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469505/
https://ncbi.nlm.nih.gov/pubmed/23071729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047122
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