Ex Vivo Effect of Varespladib on Secretory Phospholipase A2 Alveolar Activity in Infants with ARDS

BACKGROUND: Secretory phospholipase A2 (sPLA2) plays a pivotal role in acute respiratory distress syndrome (ARDS). This enzyme seems an interesting target to reduce surfactant catabolism and lung tissue inflammation. Varespladib is a specifically designed indolic sPLA2 inhibitor, which has shown pro...

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Autores principales: De Luca, Daniele, Minucci, Angelo, Piastra, Marco, Cogo, Paola E., Vendittelli, Francesca, Marzano, Laura, Gentile, Leonarda, Giardina, Bruno, Conti, Giorgio, Capoluongo, Ettore D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469496/
https://ncbi.nlm.nih.gov/pubmed/23071714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047066
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