Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II).

We report a direct technique for determining the binding sites of small molecules on naturally occurring heterogeneous DNA. Methidiumpropyl-EDTA.Fe(II) [MPE.Fe(II) cleaves double helical DNA with low sequence specificity. Using a combination of MPE.Fe(II) cleavage of drug-protected DNA fragments and...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Van Dyke, M W, Hertzberg, R P, Dervan, P B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1982
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346925/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6291045/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.18.5470
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