Nucleocytoplasmic transport blockage by SV40 peptide-modified gold nanoparticles induces cellular autophagy

Gold nanoparticles modified with the nuclear localization signal from simian virus 40 large T antigen (GNP-PEG/SV40) accumulate on the cytoplasmic side of the nuclear membrane in HeLa cells. Accumulation of GNP-PEG/SV40 around the nucleus blocks nucleocytoplasmic transport and prevents RNA export an...

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Autors principals: Tsai, Tsung-Lin, Hou, Chia-Cheng, Wang, Hao-Chen, Yang, Zih-Syuan, Yeh, Chen-Sheng, Shieh, Dar-Bin, Su, Wu-Chou
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2012
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469097/
https://ncbi.nlm.nih.gov/pubmed/23071392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S35125
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