Blocking p55PIK signaling inhibits proliferation and induces differentiation of leukemia cells

p55PIK, a regulatory subunit of phosphatidylinositol 3-kinases, promotes cell cycle progression by interacting with cell cycle modulators such as retinoblastoma protein (Rb) via its unique amino-terminal 24 amino-acid residue (N24). Overexpression of N24 specifically inhibits these interactions and...

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Autores principales: Wang, G, Deng, Y, Cao, X, Lai, S, Tong, Y, Luo, X, Feng, Y, Xia, X, Gong, J, Hu, J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469064/
https://ncbi.nlm.nih.gov/pubmed/22722333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.70
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