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Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP)
The ATP-binding cassette (ABC) transporter TAP translocates peptides from the cytosol to awaiting MHC class I molecules in the endoplasmic reticulum. TAP is made up of the TAP1 and TAP2 polypeptides, which each possess a nucleotide binding domain (NBD). However, the role of ATP in peptide binding an...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34686/ https://ncbi.nlm.nih.gov/pubmed/11381133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121180198 |
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