Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP)

The ATP-binding cassette (ABC) transporter TAP translocates peptides from the cytosol to awaiting MHC class I molecules in the endoplasmic reticulum. TAP is made up of the TAP1 and TAP2 polypeptides, which each possess a nucleotide binding domain (NBD). However, the role of ATP in peptide binding an...

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Detalles Bibliográficos
Main Authors: Karttunen, Jaana T., Lehner, Paul J., Gupta, Soma Sen, Hewitt, Eric W., Cresswell, Peter
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC34686/
https://ncbi.nlm.nih.gov/pubmed/11381133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121180198
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