Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice

Transient receptor potential channels (TRPCs) are widely expressed and regulate Ca(2+) entry in the cells that participate in the pathophysiology of airway hyperreactivity, inflammation, and remodeling. In vitro studies point to a role for TRPC1-mediated Ca(2+) signaling in several of these cell typ...

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Auteurs principaux: Yildirim, Eda, Carey, Michelle A., Card, Jeffrey W., Dietrich, Alexander, Flake, Gordon P., Zhang, Yingpei, Bradbury, J. Alyce, Rebolloso, Yvette, Germolec, Dori R., Morgan, Daniel L., Zeldin, Darryl C., Birnbaumer, Lutz
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468476/
https://ncbi.nlm.nih.gov/pubmed/22797250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00389.2011
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