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Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique
The present study was aimed to increase the solubility of the poorly water soluble drug benfotiamine using hydrophilic polymers (PVP K-30 and HPMC E4). Solid dispersions were prepared by kneading method. Phase solubility study, in-vitro dissolution of pure drug, physical mixtures and solid dispersio...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Medknow Publications & Media Pvt Ltd
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3467834/ https://ncbi.nlm.nih.gov/pubmed/23066179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0975-7406.94157 |
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