FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model

The farnesoid X receptor (FXR) is expressed predominantly in tissues exposed to high levels of bile acids and controls bile acid and lipid homeostasis. FXR(−/−) mice develop hepatocellular carcinoma (HCC) and show an increased prevalence for intestinal malignancies, suggesting a role of FXR as a tum...

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Main Authors: Deuschle, Ulrich, Schüler, Julia, Schulz, Andreas, Schlüter, Thomas, Kinzel, Olaf, Abel, Ulrich, Kremoser, Claus
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467263/
https://ncbi.nlm.nih.gov/pubmed/23056173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043044
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