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Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling.

Negative supercoiling of plasmid DNAs containing 24--42 base pairs of alternating d(pCpG) inserts is shown to cause the flipping of the helical hand of the inserts from right to left under physiological conditions. For a negatively supercoiled DNA with a fixed linking number, this flipping reduces i...

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Dettagli Bibliografici
Autori principali: Peck, L J, Nordheim, A, Rich, A, Wang, J C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1982
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC346714/
https://ncbi.nlm.nih.gov/pubmed/6956879
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