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PPARγ agonists target aromatase via both PGE(2) and BRCA1

Obesity is a well-recognized risk factor for postmenopausal breast cancer. Although the underlying mechanisms are not clearly defined, aromatase is thought to play a pivotal role in connecting obesity-associated inflammation with postmenopausal breast cancer. It has been well established that both t...

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Autors principals: Margalit, Ofer, Wang, Dingzhi, DuBois, Raymond N.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466470/
https://ncbi.nlm.nih.gov/pubmed/23041473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-12-0365
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