Angiogenesis Inhibitor Vasohibin-1 Enhances Stress Resistance of Endothelial Cells via Induction of SOD2 and SIRT1

Vasohibin-1 (VASH1) is isolated as an endothelial cell (EC)-produced angiogenesis inhibitor. We questioned whether VASH1 plays any role besides angiogenesis inhibition, knocked-down or overexpressed VASH1 in ECs, and examined the changes of EC property. Knock-down of VASH1 induced premature senescen...

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Detalhes bibliográficos
Main Authors: Miyashita, Hiroki, Watanabe, Tatsuaki, Hayashi, Hideki, Suzuki, Yasuhiro, Nakamura, Takanobu, Ito, Soichi, Ono, Manabu, Hoshikawa, Yasushi, Okada, Yoshinori, Kondo, Takashi, Sato, Yasufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466306/
https://ncbi.nlm.nih.gov/pubmed/23056314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046459
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