Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice

We have demonstrated that treating diet-induced obese (DIO) mice with the vasopeptidase inhibitor ilepatril improved neural function. Vasopeptidase inhibitors block angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) activity. We propose that increased activity of ACE and NEP contrib...

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Hlavní autoři: Coppey, Lawrence, Lu, Bao, Gerard, Craig, Yorek, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465928/
https://ncbi.nlm.nih.gov/pubmed/23056927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/326806
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