Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer

OBJECTIVES: Patients with advanced squamous cell carcinoma of the head and neck (SCCHN) have limited treatment options. Inhibition of histone deacetylases (HDACs) represents a novel therapeutic approach warranting additional investigation in solid tumors. METHODS: A phase II trial of single agent ro...

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Main Authors: Haigentz, Missak, Kim, Mimi, Sarta, Catherine, Lin, Juan, Keresztes, Roger S., Culliney, Bruce, Gaba, Anu G., Smith, Richard V., Shapiro, Geoffrey I., Chirieac, Lucian R., Mariadason, John M., Belbin, Thomas J., Greally, John M., Wright, John J., Haddad, Robert I.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465519/
https://ncbi.nlm.nih.gov/pubmed/22748449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2012.05.024
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